陆苑,女,1988年生,副教授,病理学与病理生理学博士。2014年贵州医科大学药剂学留毕业留校任教至今,从事中药药效物质基础及药代动力学、药物制剂新技术研究教学和科研工作。2017.9-2018.9,在英国King’s College of London访学一年;2020.6至今,为贵州医科大学附属医院在站博士后。
近年来,主持国家自然科学基金项目(81860718),贵州省科技厅(黔科合支撑[2021]一般421)等10个科研项目;发表科研论文40余篇(其中第一作者18篇,通讯作者7篇,SCI论文11篇),发明专利2项。
发表的部分论文:
Shuai Zhang#, Yuan Lu#, Hong-Yu Jiang, Zhi-Mei Cheng, Zi-Jing Wei, Yun-Hao Wei, Ting Liu, Bai-Juan Xia, Xu-Ya Zhao, Yu Huang, Xun Zou, Rong Liu, and Shi Zhou*. CircC16orf62 promotes Hepatocellular carcinoma progression through the miR-138-5p/PTK2/AKT axis. Cell Death & Disease. (2021) 12:597. https://doi.org/10.1038/s41419-021-03866-7
Yuan Lu#, Na Li#, Xiaoqin Zhu, Jie Pan, Yonglin Wang, Yanyu Lan, Yongjun Li, Aimin Wang, Jia Sun*, Chunhua Liu*. Comparative analysis of excretion of six major compounds of Polygonum orientale L. extract in urine, feces and bile under physiological and myocardial ischemia conditions in rats using UPLC-MS/MS. Biomedical Chromatography. 2021. doi: 10.1002/bmc.5174.
Jie Pan, Yuan Lu, Yueting Li, Jia Sun, Chunhua Liu, Zipeng Gong, Jing Huang, Jiang Zheng, Yongjun Li, Yonglin Wang*, Ting Liu*. Differential Changes in the Pharmacokinetics of Doxorubicin in Diethylnitrosamine-Induced Hepatocarcinoma Model Rats. Xenobiotica. 2020;1-7. doi:10.1080/00498254.2020.1765049.
Na Li, Ting Lv, Jie Pan, Chunhua Liu, Jia Sun, Yanyu Lan, Aimin Wang, Yongjun Li, Yonglin Wang *, Yuan Lu*. Comparative tissue distribution of six major polyphenolic compounds in normal and myocardial ischemia model rats after oral administration of the extract of Polygonum orientale L. Natural Product Communications. 2020, 15(6): 1–10. DOI: 10.1177/1934578X20929447.
Zarif M. Sofian, Faiza Benaouda, Julie Tzu-Wen Wang, Yuan Lu, David J. Barlow, Paul G. Royall, Doaa B. Farag, Khondaker Miraz Rahman, Khuloud T. Al-Jamal, Ben Forbes, and Stuart A. Jones*. A Cyclodextrin-Stabilized Spermine-Tagged Drug Triplex that Targets Theophylline to the Lungs Selectively in Respiratory Emergency. Advanced Therapeutics. 2020. https://doi.org/10.1002/adtp.202000153
Jia Sun#, Yuan Lu#, Yueting Li, Jie Pan, Chunhua Liu, Zipeng Gong, Jing Huang, Jiang Zheng, Lin Zheng, Yongjun Li, Ting Liu* and Yonglin Wang*. Molecules. 2017, 1994; doi:10.3390/molecules22111994.
Yuan Lu#, ZiPeng Gong#, YuMin Xie, Jie Pan, Jia Suna,b, YueTing Li, SiYing Chen, YongJun Li, YongLin Wang* , Yong Huang*. Herb drug interaction: effects of Relinqing® granule on the pharmacokinetics of Ciprofloxacin, Sulfamethoxazole, and Trimethoprim in rats [J]. Evidence-Based Complementary and Alternative Medicine (IF=1.931), 2016, http://dx.doi.org/10.1155/2016/6194206.
Lin Zheng, Yuan Lu, Xu Cao, Yong Huang, Yue Liu, Li Tang, Shang-Gao Liao, Ai-Min Wang, Yong-Jun Li, Yan-Yu Lan, Yong-Lin Wang*. Evaluation of the impact of Polygonum capitatum, a traditional Chinese herbal medicine, on rat hepatic cytochrome P450 enzymes by using a cocktail of probe drugs [J]. Journal of Ethnopharmacology (IF=2.939), 2014, 158: 276–282.
Yueting Li, Yuan Lu, Jianchun Hu, Zipeng Gong, Wu Yang, Aimin Wang, Jiang Zheng, Ting Liu, Tingting Chen, Jie Hu, Ling Mi, Yongjun Li, Yanyu Lan, Yonglin Wang*. Pharmacokinetic comparison of scutellarin and paeoniflorin in sham-operated and middle cerebral artery occlusion ischemia and reperfusion injury rats after intravenous administration of Xin-Shao formula [J]. Molecules(IF=2.465), 2016, in press.
Lin Zheng, Zipeng Gong, Yuan Lu, Yumin Xie, Yong Huang, Yue Liu, Yanyu Lan, Aimin Wang, Yonglin Wang*. A UPLC-MS/MS method for simultaneous determination of danshensu, protocatechuic aldehyde, rosmarinic acid and ligustrazine in rats plasma and its application to pharmacokinetic study of shenxiong glucose injection in rats [J]. Journal of Chromatography B(IF=2.694), 2015, 997: 210–217.
朱晓青,陆苑,刘亭,潘洁,刘春花,李勇军,王永林*. 艾迪注射液对DEN诱导型肝癌大鼠体内细胞色素P450酶表达的影响[J]. 中国实验方剂学杂志. 2021,27(8):43-49.
陆苑, 黎娜, 刘春花, 潘洁, 李勇军, 王永林, 孙佳*. 基于在体肠袢模型研究荭草活性成分在正常及心肌缺血模型大鼠的肠吸收特性[J]. 中国药理学通报. 2020,36(8):1146-51.
潘洁,杨淑婷,孙佳,刘春花,王永林,陆苑*. 荭草中6种活性成分在正常和心肌缺血模型大鼠体内的肠吸收特征差异研究[J].中国药房. 2020,31(13): 1562-1568.
陆苑, 潘洁, 谢玉敏, 郑林, 黄勇,王永林,李勇军*. 头花蓼水提取物对CYP450酶诱导和抑制作用研究[J]. 中国药理学通报, 2015, 31(8):1147-1152.
主持的部分科研项目:
国家自然科学基金地区基金(81860718),艾迪注射液和阿霉素的协同作用及其机制研究,35万,2019.01-2022.12,在研,主持;
贵州省教育厅青年科技人才成长项目(黔教合KY字[2021]171),贵州省教育厅青年科技人才成长项目(黔教合KY字[2021]171),4万,2021.1-2023.12,在研,主持。
贵州省科技厅(黔科合支撑[2021]一般421),艾迪注射液抗肝癌和抗心衰药效物质基础及产品质量提升研究与示范,32万,2021.4.1-2024.3.30,在研,主持。
贵州省科技厅(黔科合平台人才[2017]5718),艾迪注射液和阿霉素的协同作用及其机制研究,5万,2018.01-2020.12,结题,主持。
贵州省科技厅(黔科合LH字[2015]7361),基于大鼠HCC模型的艾迪注射液药物相互作用研究,5万,2015-2017,结题,主持。
读取内容中,请等待...